It has been demonstrated that decitabine (Dacogen®) can cause DNA demethylation by inactivation of DNA Methyltransferase-1 (DNMT-1), the enzyme responsible for methylation of the DNA. The inhibition of this enzyme leads to in-gene promoter hypomethylation that can result in reactivation of tumour suppressor genes, inducing cellular differentiation or cellular senescence followed by programmed cell death.
- Dacogen® Summary of Product Characteristics. https://www.medicines.org.uk/emc/medicine/27127. [Accessed January 2017].