The Summary of Product Characteristics for Vidaza® states that the antineoplastic effects of azacitidine are thought to be achieved through various mechanisms. These include a cytotoxic effect on abnormal haematopoietic cells in the bone marrow and hypomethylation of DNA. In addition, inhibition of DNA, RNA, and protein synthesis, incorporation into RNA and DNA, and activation of DNA damage pathways.
- Vidaza® Summary of Product Characteristics. https://www.medicines.org.uk/emc/medicine/21508. [Accessed January 2017].